Ngoc Linh ginseng is a precious ginseng and has many beneficial effects on human health. What are those effects, let’s find out through the following article:
1. Prevent and treat physical weakness, increase physical strength, fight fatigue, restore health
The effects of increasing strength, increasing endurance, preventing fatigue, and restoring health are among the criteria for evaluating the effects of replenishing qi, treating physical weakness, and fighting stress (adaptogen effects). Brekhman’s exhausted swimming test (improved for application on white mice) and Cabureb’s climbing the endless rope test are often chosen to examine the strength-enhancing effects of research materials. Ngoc Linh ginseng extract powder shows the effect of increasing strength, preventing fatigue at doses ranging from 5 – 100 mg/kg. Compared with the same dose of 50 mg/kg body weight, Ngoc Linh ginseng extract powder shows the effect of increasing strength – preventing fatigue on white mice better than Korean ginseng extract powder.
2. Anti-mental fatigue, stimulating brain activity
Ngoc Linh ginseng shows effects on the central nervous system depending on the dose used. At doses less than 500 mg/kg body weight. Ngoc Linh ginseng has the effect of stimulating the central nervous system, increasing natural movement, shortening the sleep time of barbital. At doses greater than 50 mg/kg body weight, Ngoc Linh ginseng shows the effect of inhibiting the central nervous system, reducing natural movement and prolonging the sleep time of barbital.
3. Improve memory
Saponin compounds: G – Rb1, – Rg1, – Rg2 in Ngoc Linh ginseng are identified as the active ingredients that determine the effect of improving cognition, memory and restoring brain activity in some neurological diseases due to aging (antisenility effect) such as: Alzheimer’s disease, Parkinson’s disease, stroke due to cerebral ischemia.
4. Reduce stress, fight depression, reduce anxiety and stress-induced diseases
Majonosid – R2 in Ngoc Linh Ginseng has an anti-stress effect shown through the recovery of sleep shortened by stress. When tested in comparison with Ngoc Linh Ginseng, Korean Ginseng did not typically show this effect. The results show that Ngoc Linh Ginseng has an anti-stress effect, shown through the effect of restoring pathological disorders caused by psychological stress. This is the premise for using Ngoc Linh Ginseng in the treatment and recovery of psychological stress.
5. Effect on gastric ulcers caused by psychological stress
Experimental results on the effect on gastric ulcers caused by psychological stress from Ngoc Linh Ginseng extract powder and majonosid – R2, similar to the two control drugs diazepam and naloxone, show a protective effect on gastric lesions caused by psychological stress.
6. Antidepressant effects
Depression is manifested by symptoms of disorders: mood swings, insomnia, anorexia, reduced mental and physical performance, fatigue and most seriously, suicidal thoughts. According to statistics from the Central Psychiatric Hospital, the proportion of people showing symptoms of depression accounts for about 5-7%, of which women have a higher incidence. Psychological stress is one of the factors in the pathogenesis of depression caused by disturbances in the metabolism of central nervous system neurotransmitters (dopamine, noradrenaline, serotonin). Research results have demonstrated that Ngoc Linh Ginseng extract powder has antidepressant effects at a single oral dose of 200 mg/kg and a dose of 50 – 100 mg/kg when given orally for 7 days. The antidepressant effect of Ngoc Linh Ginseng extract powder is stronger than fluoxetine, a typical antidepressant (trade name ProzacR, oral dose 20 mg/kg). Majonosid – R2 (3.1 – 12.5 mg/kg, intraperitoneal injection) has also been shown to have antidepressant effects in normal animals. The test doses of Majonosid – R2 were selected based on the content of Majonosid – R2 (%) in Ngoc Linh Ginseng.
7. Anxiolytic effect
Majonosid – R2 was identified as an important active ingredient that determines the specific pharmacological effects of Ngoc Linh Ginseng. Majonosid – R2 exhibited stress-induced anxiolytic effects at a dose of 12.5 mg/kg similar to diazepam, a reference drug in the benzodiazepine group, at a dose of 1 mg/kg.
8. Anti-oxidation and anti-aging
Research on the mechanism of action of Majonosid – R2 from Ngoc Linh Ginseng in the direction of oxidative stress increasing the formation of nitric oxide free radicals and reducing the content of endogenous antioxidant glutathione (GSH) has had very good anti-oxidation and anti-aging results.
9. Effect of increasing Cytochrome P450 (CYP450) activity
(Cytochrome P450 (CYP450) is a system of 50 enzymes belonging to the monooxygenase group found in most living organisms. This powerful enzyme system plays an important role in human physiology. In animals and humans, this enzyme is present in the liver, heart, lungs, and kidneys, but is mainly concentrated in the liver. Orally administered substances, after being absorbed through the small intestine, are transferred to the liver through the portal vein. This process allows the liver, with the participation of CYP450, the main enzyme group involved in the metabolism of substances (in phase I), to have time to detoxify harmful substances before they are distributed into the circulatory system.)
Total saponin of Ngoc Linh Ginseng as well as the main active ingredient Majonosid – R2, increases the content of cytochrome P – 450 in the mitochondria, binds to cytochrome P- 450 and increases the activity of cytochrome P – 450 in the mitochondria, binds to cytochrome P- 450 and increases the activity of cytochrome P – 450. – 450 in oxidation-reduction reactions. The effect of total saponin of Ngoc Linh Ginseng is stronger than the main active ingredient Majonosid – R2 on both normal animals and animals damaged by carbon tetrachloride.
10. Enhance liver function, detoxify the liver, prevent cirrhosis, protect liver cells
Ngoc Linh Ginseng has the effect of protecting liver cells in experimental liver damage, reducing the increase in transaminase levels of GOT, GPT and GST. In addition, Ngoc Linh Ginseng also supports liver cell regeneration in a partial hepatectomy model, maintains liver biochemical function in a partial hepatectomy model, maintains liver biochemical function and stimulates the activity of the cytochrome – P450 system in liver mitochondria in experimental acute liver damage by CCL4.
11. Antibacterial effect, cures pharyngitis, especially effective against Streptocci bacteria
Ngoc Linh Ginseng shows specific antibacterial effects on strains of Staphylococcus and Streptococcus bacteria that cause pharyngitis. This is one of the specific effects of Ngoc Linh Ginseng when compared with Korean ginseng and some other medicinal plants of the Araliaceace family. The antibacterial effect of Ngoc Linh Ginseng is equivalent to some common antibiotics and does not affect benign bacteria in mice like antibiotics. Therefore, in addition to the effects of Ngoc Linh Ginseng such as increasing strength, nourishing, improving physical condition, it is also used in the prevention and treatment of inflammatory diseases; unwanted side effects commonly encountered when using antibiotics for a long time such as: diarrhea, loss of appetite, digestive disorders… are not encountered when using Ngoc Linh Ginseng.
12. Immune stimulating effect, increasing body immunity, increasing resistance
Ngoc Linh ginseng as well as the active ingredient Majonosid – R2 show the effect of increasing the phagocytic index in normal animal constitution and animal constitution with immune deficiency caused by psychological stress: the effect of stimulating the activity of the endoplasmic reticulum system of Ngoc Linh ginseng. The endoplasmic reticulum system plays an important role in maintaining internal stability and non-specific immunity. The correlation between the central nervous system and the immune system in immunodeficiency diseases caused by stress is the basis for the preventive effect of Ngoc Linh ginseng on immunodeficiency caused by stress. Ngoc Linh ginseng with anti-stress and tonic effects in which the active ingredient Majonosid – R2 has been identified as an agonist effect on the GABA – A system of the central nervous system to participate in the process of regulating disorders caused by stress.
13. Synergistic effect with cancer treatment drugs, cancer prevention
The active ingredient Majonosid – R2 shows anti-cancer effects through the inhibition of both the initiation and progression stages of mouse skin carcinoma induced by nitric oxide NOR1 as a stimulant and in combination with 12- O – tetradecanoylphorbol – 13 acetate (TPA) which increases cancer growth or by combining peroxynitrite with TPA.
14. Effects on the cardiovascular system and blood pressure
Ngoc Linh ginseng has the effect of regulating cardiovascular activity, stabilizing the heart rate when there is arrhythmia, stimulating the transmission of cardiac nerve impulses, and increasing blood pressure in cases of hypotension due to blood loss.
15. Reducing cholesterol, lipids, increasing HDL to prevent atherosclerosis, stabilizing blood sugar
One of the cardiovascular diseases that causes high morbidity and mortality in the elderly is atherosclerosis due to the accumulation of cholesterol in the blood vessel wall, increasing blood pressure and cerebrovascular accident (stroke). Ngoc Linh ginseng shows experimental anti-atherosclerosis effects by reducing blood cholesterol, reducing total lipids and lipoproteins, and increasing HDL-cholesterol content. 16. Effects of regulating sex hormones, preventing sexual weakness
Ngoc Linh ginseng extract powder has sex hormone effects (androgenic effects and estrogenic effects) during use of 9-15 days.
When comparing the effects of Ngoc Linh Ginseng with Korean Ginseng at the same dose, the sex hormone effects of Ngoc Linh Ginseng are more typical.
17. Support and synergize with drugs for treating diabetes and lowering blood pressure
Ngoc Linh Ginseng extract powder has a synergistic effect with insulin, prolonging the time of insulin’s hypoglycemic effect by 2-3 hours compared to insulin alone. Blood sugar values when combined with Ngoc Linh Ginseng and insulin are more stable than when using insulin alone.
18. Anti-inflammatory pain relief effect
Ngoc Linh ginseng extract powder has anti-chronic inflammatory effect through experimental granuloma induction method using cotton implants. This effect is shown at a dose of 180 mg/kg body weight after 7 days of use, equivalent to sodium salicylate at a dose of 300 mg/kg body weight.
In addition, Ngoc Linh ginseng extract powder also has analgesic effect in experimental abdominal pain caused by acetic acid at a dose of 90 mg/kg body weight, equivalent to sodium salicylate at a dose of 300 mg/kg body weight.
In the hot-plate pain experiment, the analgesic effect of Ngoc Linh ginseng extract powder tended to increase with the dose used and at a dose of 180 mg/kg body weight, Ngoc Linh ginseng extract powder showed a stronger effect than sodium salicylate (dose of 400 mg/kg body weight).
Above are the typical effects of Ngoc Linh Ginseng that Sam Sam Company shares with readers for reference. If you have any questions about Ngoc Linh Ginseng as well as health protection products from Ngoc Linh Ginseng, please contact us.
